Exosomes Derived from Nanocomplex-Loaded Macrophages for Targeted Delivery of Docetaxel and siPLK1 against Castrate-Resistance Prostate Cancer

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>. As a class of naturally occurring nanoparticles with low immunogenicity and high biocompatibility, exosomes have become a promising drug carrier for cancer therapy. However, their clinical applications remain a challenge due to their unsuitable donors, low scalability, as well as insufficient targeting ability. Here, we describe and validate a new strategy for dru...

Topics

Open a Topic to create a Post that cites this publication.

• Cell Communication
• Cell Movement
• Exosomes
• Mice, Nude
• Prostatic Neoplasms
• Tumor Cells, Cultured
• Tumor Microenvironment
• Xenograft Model Antitumor Assays

Identifiers and source

Literature Corpus work

0141784f-4699-5f5b-96de-039b67976962

DOI

10.21203/rs.3.rs-58910/v1