Article
Released Exosomes Contribute to the Immune Modulation of Cord Blood-Derived Stem Cells.
Frontiers in immunology - 1 Jan 2020
Hu Wei, Song Xiang, Yu Haibo, Sun Jingyu, Zhao Yong
Abstract excerpt
Background: Clinical studies demonstrated the immune modulation of cord blood-derived stem cells (CB-SC) for the treatment of type 1 diabetes and other autoimmune diseases, with long-lasting clinical efficacy. To determine the molecular mechanisms underlying the immune modulation of CB-SC, the actions of exosomes released from CB-SC were explored in this study. Methods: Exosomes were isolated from CB-SC cultures...
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