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Article

Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor

22 Sept 2014

Abstract excerpt

Autophagy is an important cellular process that serves as a companion pathway to the ubiquitin-proteasome system to degrade long-lived proteins and organelles to maintain cell homeostasis. Although initially characterized in yeast, autophagy is being realized as an important regulator of development and disease in mammals. Beclin1 (Becn1) is a putative tumor suppressor gene that has been shown to undergo a loss...

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PMID: 25246579
DOI: 10.1073/pnas.1409323111

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