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Article

Inefficient degradation of cyclin B1 re-activates the spindle checkpoint right after sister chromatid disjunction.

Cell cycle (Georgetown, Tex.) - 1 Jan 2014

Clijsters Linda, van Zon Wouter, Riet Bas Ter, Voets Erik, Boekhout Michiel, Ogink Janneke, Rumpf-Kienzl Cornelia, Wolthuis Rob M F

Abstract excerpt

Sister chromatid separation creates a sudden loss of tension on kinetochores, which could, in principle, re-activate the spindle checkpoint in anaphase. This so-called "anaphase problem" is probably avoided by timely inactivation of cyclin B1-Cdk1, which may prevent the spindle tension sensing Aurora B kinase from destabilizing kinetochore-microtubule interactions as they lose tension in anaphase. However,...

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Identifiers

PMID: 25483188
DOI: 10.4161/cc.29336
PMCID: PMC4128882

Genes

APC
INCENP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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