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Article

Molecular mechanisms regulating the defects in fragile X syndrome neurons derived from human pluripotent stem cells.

Stem cell reports - 13 Jan 2015

Halevy Tomer, Czech Christian, Benvenisty Nissim

Abstract excerpt

Fragile X syndrome (FXS) is caused by the absence of the fragile X mental retardation protein (FMRP). We have previously generated FXS-induced pluripotent stem cells (iPSCs) from patients' fibroblasts. In this study, we aimed at unraveling the molecular phenotype of the disease. Our data revealed aberrant regulation of neural differentiation and axon guidance genes in FXS-derived neurons, which are regulated by...

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Identifiers

PMID: 25483109
DOI: 10.1016/j.stemcr.2014.10.015
PMCID: PMC4297868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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