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Article

New perspectives on the biology of fragile X syndrome.

Current opinion in genetics & development - 1 Jun 2012

Wang Tao, Bray Steven M, Warren Stephen T

Abstract excerpt

Fragile X syndrome (FXS) is a trinucleotide repeat disorder caused by a CGG repeat expansion in FMR1, and loss of its protein product FMRP. Recent studies have provided increased support for the role of FMRP in translational repression via ribosomal stalling and the microRNA pathway. In neurons, particular focus has been placed on identifying the signaling pathways such as PI3K and mTOR downstream of group 1...

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Source

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Identifiers

PMID: 22382129
DOI: 10.1016/j.gde.2012.02.002
PMCID: PMC3653273

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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