Article
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.
Nature - 5 Jun 2011
Puente Xose S, Pinyol Magda, Quesada Víctor, Conde Laura, Ordóñez Gonzalo R, Villamor Neus, Escaramis Georgia, Jares Pedro, Beà Sílvia, González-Díaz Marcos, Bassaganyas Laia, Baumann Tycho, Juan Manel, López-Guerra Mónica, Colomer Dolors, Tubío José M C, López Cristina, Navarro Alba, Tornador Cristian, Aymerich Marta, Rozman María, Hernández Jesús M, Puente Diana A, Freije José M P, Velasco Gloria, Gutiérrez-Fernández Ana, Costa Dolors, Carrió Anna, Guijarro Sara, Enjuanes Anna, Hernández Lluís, Yagüe Jordi, Nicolás Pilar, Romeo-Casabona Carlos M, Himmelbauer Heinz, Castillo Ester, Dohm Juliane C, de Sanjosé Silvia, Piris Miguel A, de Alava Enrique, San Miguel Jesús, Royo Romina, Gelpí Josep L, Torrents David, Orozco Modesto, Pisano David G, Valencia Alfonso, Guigó Roderic, Bayés Mónica, Heath Simon, Gut Marta, Klatt Peter, Marshall John, Raine Keiran, Stebbings Lucy A, Futreal P Andrew, Stratton Michael R, Campbell Peter J, Gut Ivo, López-Guillermo Armando, Estivill Xavier, Montserrat Emili, López-Otín Carlos, Campo Elías
Abstract excerpt
Chronic lymphocytic leukaemia (CLL), the most frequent leukaemia in adults in Western countries, is a heterogeneous disease with variable clinical presentation and evolution. Two major molecular subtypes can be distinguished, characterized respectively by a high or low number of somatic hypermutations in the variable region of immunoglobulin genes. The molecular changes leading to the pathogenesis of the disease...
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