Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.

doi:10.1073/pnas.2336103100

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Article

Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.

Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 2003

Zambrowicz Brian P, Abuin Alejandro, Ramirez-Solis Ramiro, Richter Lizabeth J, Piggott James, BeltrandelRio Hector, Buxton Eric C, Edwards Joel, Finch Rick A, Friddle Carl J, Gupta Anupma, Hansen Gwenn, Hu Yi, Huang Wenhu, Jaing Crystal, Key Billie Wayne, Kipp Peter, Kohlhauff Buckley, Ma Zhi-Qing, Markesich Diane, Payne Robert, Potter David G, Qian Ny, Shaw Joseph, Schrick Jeff, Shi Zheng-Zheng, Sparks Mary Jean, Van Sligtenhorst Isaac, Vogel Peter, Walke Wade, Xu Nianhua, Zhu Qichao, Person Christophe, Sands Arthur T

Abstract excerpt

The availability of both the mouse and human genome sequences allows for the systematic discovery of human gene function through the use of the mouse as a model system. To accelerate the genetic determination of gene function, we have developed a sequence-tagged gene-trap library of >270,000 mouse embryonic stem cell clones representing mutations in approximately 60% of mammalian genes. Through the generation and...

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Identifiers

PMID: 14610273
DOI: 10.1073/pnas.2336103100
PMCID: PMC283554

Genes

WNK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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