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Article

Allele-specific copy number profiling by next-generation DNA sequencing.

Nucleic acids research - 27 Feb 2015

Chen Hao, Bell John M, Zavala Nicolas A, Ji Hanlee P, Zhang Nancy R

Abstract excerpt

The progression and clonal development of tumors often involve amplifications and deletions of genomic DNA. Estimation of allele-specific copy number, which quantifies the number of copies of each allele at each variant loci rather than the total number of chromosome copies, is an important step in the characterization of tumor genomes and the inference of their clonal history. We describe a new method, falcon,...

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PMID: 25477383
DOI: 10.1093/nar/gku1252
PMCID: PMC4344483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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