Article
A naturally occurring single amino acid replacement in multiple gene regulator of group A Streptococcus significantly increases virulence.
The American journal of pathology - 1 Feb 2015
Sanson Misu, O'Neill Brian E, Kachroo Priyanka, Anderson Jeff R, Flores Anthony R, Valson Chandni, Cantu Concepcion C, Makthal Nishanth, Karmonik Christof, Fittipaldi Nahuel, Kumaraswami Muthiah, Musser James M, Olsen Randall J
Abstract excerpt
Single-nucleotide polymorphisms (SNPs) are the most common source of genetic variation within a species; however, few investigations demonstrate how naturally occurring SNPs may increase strain virulence. We recently used group A Streptococcus as a model pathogen to study bacteria strain genotype-patient disease phenotype relationships. Whole-genome sequencing of approximately 800 serotype M59 group A...
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