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Article

Gene fitness landscape of group A streptococcus during necrotizing myositis

21 Jan 2019

Abstract excerpt

Necrotizing fasciitis and myositis are devastating infections characterized by high mortality. Group A streptococcus (GAS) is a common cause of these infections, but the molecular pathogenesis is poorly understood. We report a genome-wide analysis using serotype M1 and M28 strains that identified GAS genes contributing to necrotizing myositis in nonhuman primates (NHP), a clinically relevant model. Using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30667377
DOI: 10.1172/jci124994

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