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Article

Phosphatidate phosphatase activity plays key role in protection against fatty acid-induced toxicity in yeast.

The Journal of biological chemistry - 19 Aug 2011

Fakas Stylianos, Qiu Yixuan, Dixon Joseph L, Han Gil-Soo, Ruggles Kelly V, Garbarino Jeanne, Sturley Stephen L, Carman George M

Abstract excerpt

The PAH1-encoded phosphatidate (PA) phosphatase in Saccharomyces cerevisiae is a pivotal enzyme that produces diacylglycerol for the synthesis of triacylglycerol (TAG) and simultaneously controls the level of PA used for phospholipid synthesis. Quantitative lipid analysis showed that the pah1Δ mutation caused a reduction in TAG mass and an elevation in the mass of phospholipids and free fatty acids, changes that...

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Identifiers

PMID: 21708942
DOI: 10.1074/jbc.M111.258798
PMCID: PMC3190715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphatidate phosphatase activity plays key role in protection against fatty acid-induced toxicity in yeast.PMID 21708942Read ↗

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