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Article

Roles of phosphatidate phosphatase enzymes in lipid metabolism.

Trends in biochemical sciences - 1 Dec 2006

Carman George M, Han Gil-Soo

Abstract excerpt

Phosphatidate phosphatase (PAP) enzymes catalyze the dephosphorylation of phosphatidate, yielding diacylglycerol and inorganic phosphate. In eukaryotic cells, PAP activity has a central role in the synthesis of phospholipids and triacylglycerol through its product diacylglycerol, and it also generates and/or degrades lipid-signaling molecules that are related to phosphatidate. There are two types of PAP enzyme,...

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Catalytic Domain
Lipid Metabolism
Lipids
Lipodystrophy
Magnesium
Pancreatitis-Associated Proteins

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Phosphatidate Phosphatase

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PMID: 17079146
DOI: 10.1016/j.tibs.2006.10.003
PMCID: PMC1769311

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