Article
Lipin proteins and glycerolipid metabolism: Roles at the ER membrane and beyond.
Biochimica et biophysica acta. Biomembranes - 1 Sept 2017
Zhang Peixiang, Reue Karen
Abstract excerpt
The regulation of glycerolipid biosynthesis is critical for homeostasis of cellular lipid stores and membranes. Here we review the role of lipin phosphatidic acid phosphatase enzymes in glycerolipid synthesis. Lipin proteins are unique among glycerolipid biosynthetic enzymes in their ability to transit among cellular membranes, rather than remain membrane tethered. We focus on the mechanisms that underlie lipin...
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