Article
Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A.
Genesis (New York, N.Y. : 2000) - 1 Nov 2005
Niswender Colleen M, Willis Brandon S, Wallen Angela, Sweet Ian R, Jetton Thomas L, Thompson Brian R, Wu Chaodong, Lange Alex J, McKnight G Stanley
Abstract excerpt
Using the cre-loxP recombination system, we generated a line of mice expressing a constitutively active catalytic subunit of Protein Kinase A (PKA) in a temporally and spatially regulated fashion. In the absence of cre recombinase the modified catalytic subunit allele is functionally silent, but after recombination the mutant allele is expressed, resulting in enhanced PKA effects at basal cAMP levels. Mice...
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