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Article

Repair of diverse diabetic defects of β-cells in man and mouse by pharmacological glucokinase activation.

Diabetes, obesity & metabolism - 1 Oct 2012

Doliba Nicolai M, Fenner Deborah, Zelent Bogumil, Bass Joseph, Sarabu Ramakanth, Matschinsky Franz M

Abstract excerpt

Glucokinase activators (GKAs) are being developed and clinically tested for potential antidiabetic therapy. The potential benefits and limitations of this approach continue to be intensively debated. To contribute to the understanding of experimental pharmacology and therapeutics of GKAs, we have tested the efficacy of one of these agents (Piragliatin) in isolated islets from humans with type 2 diabetes mellitus...

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Identifiers

PMID: 22928571
DOI: 10.1111/j.1463-1326.2012.01652.x
PMCID: PMC4433321

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