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Article

Large-Scale trans-eQTLs Affect Hundreds of Transcripts and Mediate Patterns of Transcriptional Co-regulation.

American journal of human genetics - 6 Apr 2017

Brynedal Boel, Choi JinMyung, Raj Towfique, Bjornson Robert, Stranger Barbara E, Neale Benjamin M, Voight Benjamin F, Cotsapas Chris

Abstract excerpt

Efforts to decipher the causal relationships between differences in gene regulation and corresponding differences in phenotype have been stymied by several basic technical challenges. Although detecting local, cis-eQTLs is now routine, trans-eQTLs, which are distant from the genes of origin, are far more difficult to find because millions of SNPs must currently be compared to thousands of transcripts. Here, we...

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Identifiers

PMID: 28285767
DOI: 10.1016/j.ajhg.2017.02.004
PMCID: PMC5384037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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