Article
[KRAS mutation test].
Rinsho byori. The Japanese journal of clinical pathology - 1 Jun 2011
Hinoda Yuji
Abstract excerpt
KRAS mutation is detected in around 40% of colorectal cancer (CRC). Recent clinical trials revealed the ineffectiveness of anti-EGFR antibodies in CRC patients with mutated KRAS. Consequently, KRAS test is now thought to be essential to the determination of indication for anti-EGFR antibody therapy in CRC. However, there are still the following problems to be solved. (1) Prospective studies are needed to validate...
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