Article
KRAS mutational status in Japanese patients with colorectal cancer: results from a nationwide, multicenter, cross-sectional study.
Japanese journal of clinical oncology - 1 Jul 2013
Watanabe Toshiaki, Yoshino Takayuki, Uetake Hiroyuki, Yamazaki Kentaro, Ishiguro Megumi, Kurokawa Tatsuo, Saijo Nagahiro, Ohashi Yasuo, Sugihara Kenichi
Abstract excerpt
OBJECTIVE: KRAS gene mutations are a useful predictive factor for the efficacy of anti-epidermal growth factor receptor therapeutics. Since there were no large-scale studies among Asian populations, we designed an observational nationwide study in Japan. METHODS: Formalin-fixed paraffin-embedded tissue blocks or sections from primary or metastatic lesions were obtained from patients registered between 2009 and...
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