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Article

[Detection of KRAS gene mutation and its clinical significance in colorectal adenocarcinoma].

Zhonghua bing li xue za zhi = Chinese journal of pathology - 1 Oct 2012

Xu Chen, Liu Ya-lan, Huang Jie, He De-ming, Hou Ying-yong, Ji Yuan, Hou Jun, Lu Shao-hua, Xu Jian-fang, Hu Qin, Shi Yuan, Zhao Li-jun, Tan Yun-shan

Abstract excerpt

OBJECTIVE: To explore the clinical significance of KRAS mutation detection in colorectal adenocarcinoma. METHODS: Paraffin-embedded tissue specimens were obtained from 440 patients with colorectal adenocarcinoma. The genomic DNA was extracted. Mutations of exon 2 of KRAS gene were examined by PCR and direct sequencing. RESULTS: Somatic mutations of KRAS gene were identified in 146 cases, with the mutation rate of...

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Source

Identifiers

PMID: 23302307
DOI: 10.3760/cma.j.issn.0529-5807.2012.10.005

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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