Article
Adenosine A2A receptor, a potential valuable target for controlling reoxygenated DCs-triggered inflammation.
Molecular immunology - 1 Feb 2015
Liu Chunmei, Shang Qianwen, Bai Yang, Guo Chun, Zhu Faliang, Zhang Lining, Wang Qun
Abstract excerpt
Dendritic cells (DCs) exposed to various oxygen tensions under physiopathological conditions are the critical immune cells linking innate and adaptive immunity. We have previously demonstrated that reoxygenation of hypoxia-differentiated DCs triggers complete DCs activation and inflammatory responses, so restraining the activation of reoxygenated DCs is important to suppress inflammatory responses in diseases...
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