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Article

Impact of prostate inflammation on lesion development in the POET3(+)Pten(+/-) mouse model of prostate carcinogenesis.

The American journal of pathology - 1 Dec 2014

Burcham Grant N, Cresswell Gregory M, Snyder Paul W, Chen Long, Liu Xiaoqi, Crist Scott A, Henry Michael D, Ratliff Timothy L

Abstract excerpt

Evidence linking prostatitis and prostate cancer development is contradictory. To study this link, the POET3 mouse, an inducible model of prostatitis, was crossed with a Pten-loss model of prostate cancer (Pten(+/-)) containing the ROSA26 luciferase allele to monitor prostate size. Prostatitis was induced, and prostate bioluminescence was tracked over 12 months, with lesion development, inflammation, and cytokine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25455686
DOI: 10.1016/j.ajpath.2014.08.021
PMCID: PMC4258501

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