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Article

Slow disease progression in a C57BL/6 pten-deficient mouse model of prostate cancer.

The American journal of pathology - 1 Jul 2011

Svensson Robert U, Haverkamp Jessica M, Thedens Daniel R, Cohen Michael B, Ratliff Timothy L, Henry Michael D

Abstract excerpt

Prostate-specific deletion of Pten in mice has been reported to recapitulate histological progression of human prostate cancer. To improve on this model, we introduced the conditional ROSA26 luciferase reporter allele to monitor prostate cancer progression via bioluminescence imaging and extensively backcrossed mice onto the albino C57BL/6 genetic background to address variability in tumor kinetics and to enhance...

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Identifiers

PMID: 21703427
DOI: 10.1016/j.ajpath.2011.03.014
PMCID: PMC3123867

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