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Article

Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy.

Cell death and differentiation - 1 Mar 2010

Jiang M, Fernandez S, Jerome W G, He Y, Yu X, Cai H, Boone B, Yi Y, Magnuson M A, Roy-Burman P, Matusik R J, Shappell S B, Hayward S W

Abstract excerpt

Peroxisome proliferator-activated receptor-gamma (PPARgamma) regulates the interface between cellular lipid metabolism, redox status and organelle differentiation. Conditional prostatic epithelial knockout of PPARgamma in mice resulted in focal hyperplasia which developed into mouse prostatic int...

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Identifiers

PMID: 19834493
DOI: 10.1038/cdd.2009.148
PMCID: PMC2821953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19834493-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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