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Immune dysregulation in the prostates of C57BL/6 <sup>Aire-/-</sup> mice mirrors that seen in human benign prostatic hyperplasia

2025-08-15

Abstract excerpt

Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging men, resulting in significant morbidity. The etiologies of BPH are unknown, though chronic prostatic inflammation is known to promote hyperplasia, fibrotic remodeling, and therapeutic resistance in BPH. BPH is highly complex and heterogeneous, presenting with varying degrees of stromal and epithelial proliferation, fibrosis, inflammati...

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Identifiers and source

Literature Corpus work
61ed424c-09c8-5679-934f-37cd58a38b3f
DOI
10.1101/2025.08.12.669857
Open publication

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Immune dysregulation in the prostates of C57BL/6 <sup>Aire-/-</sup> mice mirrors that seen in human benign prostatic hyperplasiaDOI 10.1101/2025.08.12.669857
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