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Article

A stably expressed llama single-domain intrabody targeting Rev displays broad-spectrum anti-HIV activity.

Antiviral research - 1 Dec 2014

Boons Eline, Li Guangdi, Vanstreels Els, Vercruysse Thomas, Pannecouque Christophe, Vandamme Anne-Mieke, Daelemans Dirk

Abstract excerpt

The HIV Rev protein mediates the transport of partially and unspliced HIV mRNA from the nucleus to the cytoplasm. Rev multimerizes on a secondary stem-loop structure present in the viral intron-containing mRNA species and recruits the cellular karyopherin CRM1 to export viral mRNAs from the nucleus to the cytoplasm. Previously we have identified a single-domain intrabody (Nb(190)), derived from a llama...

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Identifiers

PMID: 25453342
DOI: 10.1016/j.antiviral.2014.10.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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