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Identification of Molecular Determinants from Moloney Leukemia Virus 10 Homolog (MOV10) Protein for Virion Packaging and Anti-HIV-1 Activity

22 Nov 2011

Abstract excerpt

Discovery of novel antiretroviral mechanism is essential for the design of innovative antiretroviral therapy. Recently, we and others reported that ectopic expression of Moloney leukemia virus 10 (MOV10) protein strongly inhibits retrovirus replication. MOV10, a putative RNA helicase, can be packaged into HIV-1 virions by binding to the nucleocapsid (NC) region of Gag and inhibit viral replication at a postentry...

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PMID: 22105071
DOI: 10.1074/jbc.m111.309831

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Identification of Molecular Determinants from Moloney Leukemia Virus 10 Homolog (MOV10) Protein for Virion Packaging and Anti-HIV-1 ActivityPMID 22105071Read ↗

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