Article

ER reorganization and intracellular retention of CD58 are functionally independent properties of the human cytomegalovirus ER resident glycoprotein UL148

2019-08-24

Abstract excerpt

<h4>ABSTRACT</h4> The human cytomegalovirus (HCMV) endoplasmic reticulum (ER)-resident glycoprotein UL148 is posited to play roles in immune evasion and regulation of viral cell tropism. UL148 prevents cell surface presentation of the immune cell costimulatory ligand CD58 while promoting maturation and virion incorporation of glycoprotein O, a receptor binding subunit for an envelope glycoprotein complex involved...

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Literature Corpus work: 359ac377-4c81-5cc2-a512-ecba53d020c1
DOI: 10.1101/746438

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