Article

Ultrasensitive quantification of HIV-1 cell-to-cell transmission in primary human CD4 <sup>+</sup> T cells measures viral sensitivity to broadly neutralizing antibodies

2023-09-09

Abstract excerpt

<h4>ABSTRACT</h4> HIV-1 efficiently replicates in vivo by direct transmission from infected to uninfected CD4 + T cells at confined local sites designated virological synapses (VSs). VSs are formed by cell junctions between HIV-1 envelope glycoproteins (Envs) on an infected cell and CD4 on an uninfected cell. These sites facilitate highly efficient viral transmission and contribute to HIV-1 evasion from neutral...

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Literature Corpus work: 659578e1-3cb4-506c-87b3-5693a077dbed
DOI: 10.1101/2023.09.08.556871

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