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Article

Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles.

AIDS research and human retroviruses - 1 Nov 2018

Arizala Jerlisa Ann C, Takahashi Mayumi, Burnett John C, Ouellet Dominique L, Li Haitang, Rossi John J

Abstract excerpt

Combination antiretroviral therapy fails in complete suppression of HIV-1 due to drug resistance and persistent latency. Novel therapeutic intervention requires knowledge of intracellular pathways responsible for viral replication, specifically those untargeted by antiretroviral drugs. An understudied phenomenon is the nucleolar localization of Rev phosphoprotein, which completes nucleocytoplasmic transport of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29804468
DOI: 10.1089/AID.2017.0306
PMCID: PMC6238656

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Source receipt: pubmed, retrieved 7 Sept 2026.

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