Article
Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev.
PloS one - 1 Jan 2013
Vercruysse Thomas, Boons Eline, Venken Tom, Vanstreels Els, Voet Arnout, Steyaert Jan, De Maeyer Marc, Daelemans Dirk
Abstract excerpt
HIV-1 Rev is the key protein in the nucleocytoplasmic export and expression of the late viral mRNAs. An important aspect for its function is its ability to multimerize on these mRNAs. We have recently identified a llama single-domain antibody (Nb190) as the first inhibitor targeting the Rev multimerization function in cells. This nanobody is a potent intracellular antibody that efficiently inhibits HIV-1 viral...
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