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Article

Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence

1 Dec 2014

Abstract excerpt

It is widely believed that epidemics in new hosts diminish in virulence over time, with natural selection favoring pathogens that cause minimal disease. However, a tradeoff frequently exists between high virulence shortening host survival on the one hand but allowing faster transmission on the other. This is the case in HIV infection, where high viral loads increase transmission risk per coital act but reduce...

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PMID: 25453107
DOI: 10.1073/pnas.1413339111

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