Article
Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations.
PloS one - 22 Apr 2011
Huang Kuan-Hsiang Gary, Goedhals Dominique, Carlson Jonathan M, Brockman Mark A, Mishra Swati, Brumme Zabrina L, Hickling Stephen, Tang Christopher S W, Miura Toshiyuki, Seebregts Chris, Heckerman David, Ndung'u Thumbi, Walker Bruce, Klenerman Paul, Steyn Dewald, Goulder Philip, Phillips Rodney, van Vuuren Cloete, Frater John
Abstract excerpt
We lack the understanding of why HIV-infected individuals in South Africa progress to AIDS. We hypothesised that in end-stage disease there is a shifting dynamic between T cell imposed immunity and viral immune escape, which, through both compensatory and reverting viral mutations, results in increased viral fitness, elevated plasma viral loads and disease progression. We explored how T cell responses, viral...
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