Article
RNA polymerase II contributes to preventing transcription-mediated replication fork stalls.
The EMBO journal - 13 Jan 2015
Felipe-Abrio Irene, Lafuente-Barquero Juan, García-Rubio María L, Aguilera Andrés
Abstract excerpt
Transcription is a major contributor to genome instability. A main cause of transcription-associated instability relies on the capacity of transcription to stall replication. However, we know little of the possible role, if any, of the RNA polymerase (RNAP) in this process. Here, we analyzed 4 specific yeast RNAPII mutants that show different phenotypes of genetic instability including hyper-recombination, DNA...
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