Article
Paf1 Counteracts transcriptional arrest to maintain rDNA stability during pol I elongation.
Cell reports - 28 Jul 2026
Zhong Zijun, Yokoyama Masaaki, Kobayashi Takehiko
Abstract excerpt
Genomic instability drivers of senescence and carcinogenesis. The ribosomal RNA gene (rDNA) locus in budding yeast provides an excellent model to study these processes. Because of its highly repetitive structure and the gene amplification system that maintains its copy number, rDNA represents one of the most unstable regions in the genome. Here, we demonstrate that the integrity of rDNA transcription is essential...
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