Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paf1 Counteracts transcriptional arrest to maintain rDNA stability during pol I elongation.

Cell reports - 28 Jul 2026

Zhong Zijun, Yokoyama Masaaki, Kobayashi Takehiko

Abstract excerpt

Genomic instability drivers of senescence and carcinogenesis. The ribosomal RNA gene (rDNA) locus in budding yeast provides an excellent model to study these processes. Because of its highly repetitive structure and the gene amplification system that maintains its copy number, rDNA represents one of the most unstable regions in the genome. Here, we demonstrate that the integrity of rDNA transcription is essential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Breaks, Double-Stranded
Share to DNA Replication
Share to DNA, Ribosomal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Nuclear Proteins

Share to RNA Polymerase I

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Identifiers

PMID: 42348416
DOI: 10.1016/j.celrep.2026.117600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Paf1 Counteracts transcriptional arrest to maintain rDNA stability during pol I elongation.PMID 42348416Read ↗

Defects in the NuA4 acetyltransferase complex increase stability of the ribosomal RNA gene and extend replicative lifespan.Semantic proximity Read ↗

Fork-barrier-independent roles of topoisomerase I in the ribosomal DNA.Semantic proximity Read ↗

Repeat expansion in the budding yeast ribosomal DNA can occur independently of the canonical homologous recombination machinery.Semantic proximity Read ↗

A CSB-PAF1C axis restores processive transcription elongation after DNA damage repairSemantic proximity Read ↗

RNA Polymerase II-mediated transcription is required for repair of ribosomal DNA breaks in nucleolar caps, guarding against genomic instabilitySemantic proximity Read ↗

Rif1: A Conserved Regulator of DNA Replication and Repair Hijacked by Telomeres in YeastsSemantic proximity Read ↗

Dynamics of age-related catastrophic mitotic failures and recovery in yeastSemantic proximity Read ↗

Ctf4 Prevents Genome Rearrangements by Suppressing DNA Double-Strand Break Formation and Its End Resection at Arrested Replication Forks.Semantic proximity Read ↗

Interstitial telomeric sequences promote gross chromosomal rearrangement via multiple mechanismsSemantic proximity Read ↗

Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites.Semantic proximity Read ↗

RNA polymerase II contributes to preventing transcription-mediated replication fork stalls.Semantic proximity Read ↗

Transcription of ribosomal genes can cause nondisjunction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.