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Article

T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex.

Molecular and cellular biology - 1 Jun 2017

Breuning Johannes, Brown Marion H

Abstract excerpt

The cell surface receptor CD6 regulates T cell activation in both activating and inhibitory manners. The adaptor protein SLP-76 is recruited to the phosphorylated CD6 cytoplasmic Y662 residue during T cell activation, providing an activating signal to T cells. In this study, a biochemical approach identified the SH2 domain-containing adaptor protein GADS as the dominant interaction partner for the CD6 cytoplasmic...

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Share to Antigens, Differentiation, T-Lymphocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28289074
DOI: 10.1128/MCB.00071-17
PMCID: PMC5440646

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T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex.PMID 28289074Read ↗

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