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Article

Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT.

Science signaling - 26 Sept 2017

Sukenik Sigalit, Frushicheva Maria P, Waknin-Lellouche Cecilia, Hallumi Enas, Ifrach Talia, Shalah Rose, Beach Dvora, Avidan Reuven, Oz Ilana, Libman Evgeny, Aronheim Ami, Lewinson Oded, Yablonski Deborah

Abstract excerpt

The accurate assembly of signalosomes centered on the adaptor protein LAT (linker of activated T cells) is required for antigen receptor signaling in T cells and mast cells. During signalosome assembly, members of the growth factor receptor-bound protein 2 (Grb2) family of cytosolic adaptor proteins bind cooperatively to LAT through interactions with its phosphorylated tyrosine (pTyr) residues. We demonstrated...

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Share to GRB2 Adaptor Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28951535
DOI: 10.1126/scisignal.aal1482

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT.PMID 28951535Read ↗

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