Article
The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2000
Liu S K, Smith C A, Arnold R, Kiefer F, McGlade C J
Abstract excerpt
The hemopoietic-specific Gads (Grb2-related adaptor downstream of Shc) adaptor protein possesses amino- and carboxyl-terminal Src homology 3 (SH3) domains flanking a central SH2 domain and a unique region rich in glutamine and proline residues. Gads functions to couple the activated TCR to distal signaling events through its interactions with the leukocyte-specific signaling proteins SLP-76 (SH2 domain-containing...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Animals
- Carrier Proteins
- Cell Line
- Enzyme Activation
- Lymphocyte Activation
- Mice
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Phosphorylation
- Proline