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Article

Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells.

Molecular and cellular biology - 1 Mar 2006

Silverman Michael A, Shoag Jonathan, Wu Jennifer, Koretzky Gary A

Abstract excerpt

We developed a confocal real-time imaging approach that allows direct observation of the subcellular localization pattern of proteins involved in proximal FcepsilonRI signaling in RBL cells and primary bone marrow-derived mast cells. The adaptor protein Src homology 2 (SH2) domain-containing leuk...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16479002
DOI: 10.1128/MCB.26.5.1826-1838.2006
PMCID: PMC1430252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16479002-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells.PMID 16479002Read ↗

Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function.Semantic proximity Read ↗

SRC homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor (TCR) signaling.Semantic proximity Read ↗

T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.Semantic proximity Read ↗

A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.Semantic proximity Read ↗

Differential role of SLP-76 domains in T cell development and function.Semantic proximity Read ↗

Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.Semantic proximity Read ↗

T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex.Semantic proximity Read ↗

The chemokine CXCL12 generates costimulatory signals in T cells to enhance phosphorylation and clustering of the adaptor protein SLP-76.Semantic proximity Read ↗

Modulation of TCR responsiveness by the Grb2-family adaptor, Gads.Semantic proximity Read ↗

A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation.Semantic proximity Read ↗

Functional hierarchy of the N-terminal tyrosines of SLP-76.Semantic proximity Read ↗

SLP-65 signal transduction requires Src homology 2 domain-mediated membrane anchoring and a kinase-independent adaptor function of Syk.Semantic proximity Read ↗

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