Genetic analysis of the Warburg effect in yeast.

Abstract excerpt

We recently discovered that the Warburg effect, defined by the dramatically enhanced metabolism of glucose to pyruvate, even in well-oxygenated cancer cells, can occur as a consequence of mutations that enhance lipid biosynthesis at the expense of respiratory capacity. Specifically, mutations in the E1 subunit of either of two respiratory enzymes, pyruvate dehydrogenase (PDC) or α-ketoglutarate dehydrogenase...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Energy Metabolism
• Share to PDC gene
• Share to Glucose