Article
Grubraw, a chemogenetic mitochondrial activator, reveals new mechanisms underlying the Warburg effect
2023-04-20
Abstract excerpt
Upregulation of glycolysis and downregulation of mitochondrial oxidative phosphorylation, termed as the Warburg effect, are characteristic of tumor cells 1,2 . Restriction of pyruvate flux into the mitochondrial matrix is one of the major mechanisms underlying this phenomenon 3 . Warburg-type metabolism is beneficial for rapidly proliferating cells, however its function remains unclear. Moreover, it is unknown w...
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Identifiers and source
- Literature Corpus work
- d3568dcc-9021-5620-a13c-c078fb32b29a
- DOI
- 10.1101/2023.04.18.537329