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Optimization of central carbon metabolism by Warburg effect of human cancer cell improves triterpenes biosynthesis in yeast

26 Oct 2023

Abstract excerpt

Optimizing central carbon metabolism (CCM) represents an attractive and challenging strategy to improve the biosynthesis of valuable chemicals due to the complex regulation of the CCM in yeast. In this study, we triggered the similar Warburg effect of cancer cells in yeast strains by introducing the human hypoxia-inducible factor-1 (HIF-1) complex, which regulated the expression of numerous enzymes involved in...

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PMID: 39883335
DOI: 10.1007/s44307-023-00004-6

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