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Article

p53 regulates mitochondrial respiration.

Science (New York, N.Y.) - 16 Jun 2006

Matoba Satoaki, Kang Ju-Gyeong, Patino Willmar D, Wragg Andrew, Boehm Manfred, Gavrilova Oksana, Hurley Paula J, Bunz Fred, Hwang Paul M

Abstract excerpt

The energy that sustains cancer cells is derived preferentially from glycolysis. This metabolic change, the Warburg effect, was one of the first alterations in cancer cells recognized as conferring a survival advantage. Here, we show that p53, one of the most frequently mutated genes in cancers, modulates the balance between the utilization of respiratory and glycolytic pathways. We identify Synthesis of...

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Share to Adenosine Triphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mitochondria, Liver

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Identifiers

PMID: 16728594
DOI: 10.1126/science.1126863

Genes

SCO2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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