Model-driven analysis reveals oxidative stress adaptation enabling efficient energy utilization in a Crabtree-negative Saccharomyces cerevisiae.

Abstract excerpt

Although abolishing the Crabtree effect in Saccharomyces cerevisiae through a pyruvate dehydrogenase bypass eliminates carbon loss through ethanol overflow metabolism, it compromises growth rates. While the Crabtree effect has been a valuable natural adaptation, it is energetically inferior to respiration and is generally undesirable in cell factories engineered to produce assimilatory compounds. Restoring growth...

Topics

• Saccharomyces cerevisiae
• Oxidative Stress
• Saccharomyces cerevisiae Proteins
• Energy Metabolism
• Mutation
• Adaptation, Physiological