Article
DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4⁺ T-cell function without causing severe combined immunodeficiency.
The Journal of allergy and clinical immunology - 1 Feb 2015
Ghonim Mohamed A, Pyakurel Kusma, Ju Jihang, Rodriguez Paulo C, Lammi Matthew R, Davis Christian, Abughazleh Mohammad Q, Mansy Moselhy S, Naura Amarjit S, Boulares A Hamid
Abstract excerpt
BACKGROUND: We reported that DNA-dependent protein kinase (DNA-PK) is critical for the expression of nuclear factor κB-dependent genes in TNF-α-treated glioblastoma cells, suggesting an involvement in inflammatory diseases. OBJECTIVE: We sought to investigate the role of DNA-PK in asthma. METHODS: Cell culture and ovalbumin (OVA)- or house dust mite-based murine asthma models were used in this study. RESULTS:...
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