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Article

DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity.

Biochimica et biophysica acta - 1 Jan 2008

Liiv Ingrid, Rebane Ana, Org Tõnis, Saare Mario, Maslovskaja Julia, Kisand Kai, Juronen Erkki, Valmu Leena, Bottomley Matthew James, Kalkkinen Nisse, Peterson Pärt

Abstract excerpt

The autoimmune regulator (AIRE) protein is a key mediator of the central tolerance for tissue specific antigens and is involved in transcriptional control of many antigens in thymic medullary epithelial cells (mTEC). Mutations in the AIRE gene cause a rare disease named autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Here we report using GST pull-down assay, mass-spectrometry and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 17997173
DOI: 10.1016/j.bbamcr.2007.09.003
PMCID: PMC2225445

Genes

AIRE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity.PMID 17997173Read ↗

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AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity.Semantic proximity Read ↗

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