Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells.

PloS one - 1 Jan 2014

Wachowicz Katarzyna, Hermann-Kleiter Natascha, Meisel Marlies, Siegmund Kerstin, Thuille Nikolaus, Baier Gottfried

Abstract excerpt

Protein kinase C θ (PKCθ) is involved in signaling downstream of the T cell antigen receptor (TCR) and is important for shaping effector T cell functions and inflammatory disease development. Acquisition of Th1-like effector features by Th17 cells has been linked to increased pathogenic potential. However, the molecular mechanisms underlying Th17/Th1 phenotypic instability remain largely unknown. In the current...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Encephalomyelitis, Autoimmune, Experimental
Share to Interleukin-23

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Myelin-Oligodendrocyte Glycoprotein

Share to STAT1 Transcription Factor

Share to STAT4 Transcription Factor

Share to T-bet Transcription Factor

Share to T-Box Domain Proteins

Share to Th17 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 24788550
DOI: 10.1371/journal.pone.0096401
PMCID: PMC4008503

Genes

STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells.PMID 24788550Read ↗

PKC-Theta in Regulatory and Effector T-cell FunctionsSemantic proximity Read ↗

Loss-of-function phenotype of a PKCθT219A knockin mouse strain.Semantic proximity Read ↗

Mice deficient in PKC theta demonstrate impaired<i>in vivo</i>T cell activation and protection from T cell-mediated inflammatory diseasesSemantic proximity Read ↗

Protein kinase C η is required for T cell activation and homeostatic proliferation.Semantic proximity Read ↗

Involvement of distinct PKC gene products in T cell functionsSemantic proximity Read ↗

PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription.Semantic proximity Read ↗

Protein kinase C theta (PKCtheta): a key player in T cell life and death.Semantic proximity Read ↗

Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cellsSemantic proximity Read ↗

The atypical PKCs in inflammation: NF‐κB and beyondSemantic proximity Read ↗

Mutation of the Polyproline Sequence in CD3ε Evidences TCR Signaling Requirements for Differentiation and Function of Pro-Inflammatory Tγδ17 Cells.Semantic proximity Read ↗

PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes.Semantic proximity Read ↗

Protein Kinase Cδ Promotes Transitional B Cell-Negative Selection and Limits Proximal B Cell Receptor Signaling To Enforce ToleranceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.