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Article

Cross-tissue and tissue-specific eQTLs: partitioning the heritability of a complex trait.

American journal of human genetics - 6 Nov 2014

Torres Jason M, Gamazon Eric R, Parra Esteban J, Below Jennifer E, Valladares-Salgado Adan, Wacher Niels, Cruz Miguel, Hanis Craig L, Cox Nancy J

Abstract excerpt

Top signals from genome-wide association studies (GWASs) of type 2 diabetes (T2D) are enriched with expression quantitative trait loci (eQTLs) identified in skeletal muscle and adipose tissue. We therefore hypothesized that such eQTLs might account for a disproportionate share of the heritability estimated from all SNPs interrogated through GWASs. To test this hypothesis, we applied linear mixed models to the...

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Identifiers

PMID: 25439722
DOI: 10.1016/j.ajhg.2014.10.001
PMCID: PMC4225593

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