Article
Shared genetic architecture and casual relationship between leptin levels and type 2 diabetes: large-scale cross-trait meta-analysis and Mendelian randomization analysis.
BMJ open diabetes research & care - 1 Apr 2020
Wang Xinpei, Jia Jinzhu, Huang Tao
Abstract excerpt
OBJECTIVE: We aimed to estimate genetic correlation, identify shared loci and test causality between leptin levels and type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: Our study consists of three parts. First, we calculated the genetic correlation of leptin levels and T2D or glycemic traits by using linkage disequilibrium score regression analysis. Second, we conducted a large-scale genome-wide cross-trait...
Topics
- Diabetes Mellitus, Type 2
- Female
- Genome-Wide Association Study
- Humans
- Leptin
- Mendelian Randomization Analysis
- Phenotype
- Pregnancy