Article

Integrative cross tissue analysis of gene expression identifies novel type 2 diabetes genes

2017-02-13

Abstract excerpt

To understand the mechanistic underpinnings of type 2 diabetes (T2D) loci mapped through GWAS, we performed a tissue-specific gene association study in a cohort of over 100K individuals ( n cases ≈ 26K, n controls ≈ 84K) across 44 human tissues using MetaXcan, a summary statistics extension of PrediXcan. We found that 90 genes significantly (FDR < 0.05) associated with T2D, of which 24 are previously reported T...

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Literature Corpus work: e6575e6c-7283-585a-b92e-406425fffb26
DOI: 10.1101/108134

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